Annotation: The article analyzes the features of legal regulation of the GMOs in Ukraine. Analyzed the opinions of scientists about the safety of genetically modified organisms are diverging. The author notes that some the potential impact of genetically modified organisms on the environment and human health is one of the most controversial issues in society today. The features of legal regulation of the use of genetically modified organisms in the EU countries are studied. Ukrainian legislation, scientific literature and legal regulation of the genetically modified organisms usage in foreign countries were analyzed. The current state of the legislation regarding this issue in Ukraine is determined and possible directions for its improvement are outlined.