Tag: SCFA

Анотація: (English) This article examines the impact of different diet types, plant‐based and Western, on the composition and functional state of the gut microbiota, its metabolites, and related immunometabolic processes. The relevance of this study is rooted in the key role of the microbiota as an “auxiliary organ” that synthesizes vitamins, regulates energy metabolism, and shapes immune tolerance through the production of short‐chain fatty acids (SCFAs), which account for a substantial portion of interindividual differences attributable specifically to diet. This work aims to systematically describe and quantitatively assess changes in taxonomy, metabolomes, and markers of barrier function and inflammation when switching to plant‐based versus Western dietary patterns, drawing on the latest metagenomic cohorts, intervention studies, and multi‐omic analyses. Methodologically, the study combines metagenomics (shotgun sequencing, 16S rRNA), gas chromatography-mass spectrometry of SCFAs, measurement of permeability and inflammation markers (CRP, IL‐6, TNF-α, zonulin, LBP), and multivariate statistical models. The novelty of this work lies in the integration of large‐scale population data with controlled intervention results, which not only confirmed a consistent increase in butyrate‐producing genera and SCFA levels on plant‐based diets but also traced in detail the molecular mechanisms of their anti‐inflammatory action via GPR41/43 receptors and histone deacetylase inhibition, while juxtaposing these effects against dysbiosis, endotoxemia, and chronic inflammation observed with Western‐type diets. This article will be valuable to dietitians, microbiologists, clinical researchers, and preventive medicine specialists interested in evidence‐based microbiota modulation through rational nutrition.